In a healthy body, small amounts of bile enter the bloodstream where it acts as a natural ‘detergent’ to rancid fat in the arteries.  Rendering this rancid fat water soluble allows it to be urinated out and replaced with healthy fats.  If there are metal toxins in the body, they hydrogenate the lipids of the body into trans fatty acids (think Crisco) and cause cholesterol to crystallize where its sharp edges pierce cells from the inside causing inflammation and damage.  In this case, the natural amount of bile in the bloodstream may be insufficient.  Cholephage may support the body in increasing bloodstream bile.