As we age, and with exposure to toxic metals and organophosphates, healthy fats, waxes (ceramides) and proteins can turn into toxic fats (rancid fats and cholesterol crystals), metal soaps (toxic waxes) and prions (toxic proteins).  These are insoluble and in the case of prions, also resist enzymatic degradation.  Cyclodextrins may support the body in solubilizing and binding these toxic substances.